When using Boldore's "Smack Down" attack that does 60 more damage if the Defending Pokemon has Resistance to Fighting, does that mean it gets to ignore the Resistance altogether?
No, it does not. You do the Base 20 damage first, then add the +60 damage, and then subtract for the Fighting Resistance amount.
Source: Emerging Powers FAQ (2011-09-01), PUI Rules Team (2011-09-01)