If I play Lysandre {*} when my opponent has Shiftry's "Shifty Substitution" Ability in effect, does Lysandre {*} go to the Lost Zone or not after it has been played?
Shifty Substitution does not affect the Prism Star rule, so Lysandre {*} would go to the Lost Zone.
Source: TPCi Rules Team (2020-12-10)