If Genesect EX uses "G Booster" to attack a Pokemon with Grass Weakness but that Pokemon has a Weakness Policy Tool attached, is Weakness applied or not?
G Booster isn't affected by "any effects on the Defending Pokemon", but the term "any effects" does not include effects that alter Weakness or Resistance. So in this case, Weakness is NOT applied.
Source: TPCi Rules Team (2015-02-26), TPCi Rules Changes Announcement (2017-05-03), TPCi Rules Changes Announcement (2017-05-18)
Would Genesect EX be able to attack with "G-Booster" if the Defending Pokemon has Silver Mirror attached?
G Booster gets through because it ignores all effects on the Defending Pokemon, including Silver Mirror.
Source: TPCi Rules Team (2013-08-15)