If I use Fantina and then my Flying Pikachu V with Big Parasol attached uses its "Fly" attack and successfully lands heads, would my opponent's Giratina V's "Shred" attack do any damage to Flying Pikachu V or not?
Shred isn't affected by "any effects on the Defending Pokemon"; so the effects from Fantina and Big Parasol and Fly would all be ignored, and Shred would do damage.
Source: TPCi Rules Team (2022-09-29)
If I have 5 cards in my Lost Zone and my opponent has 5 cards in their Lost Zone, can I use Sableye's "Lost Mine" or Giratina VSTAR's "Star Requiem" attack or Fantina?
No. Each player has a separate Lost Zone above their Prize Cards that they put cards into. You yourself must have 10 cards in your Lost Zone in order to do either of those attacks or to play Fantina.
Source: Lost Origin FAQ; TPCi Rules Team (2022-09-08)