You can do any part of Red & Blue as long as there's a Pokemon in play that can evolve into a Pokemon-GX AND there's at least 1 card in your deck.
Source: Cosmic Eclipse FAQ (2019-10-18), TPCi Rules Team (2019-10-31)

Relevant cards

Note: All applicable cards may not be listed below.
SM12_202
SM12_202
SM12_234
SM12_234