For Dedenne's "Dedechange" Ability, can I use it if I have no hand to discard?
Yes, you can. A hand of zero cards is still a hand, so you would discard nothing and then draw six cards.
Source: Unbroken Bonds FAQ (2019-04-19), TPCi Rules Team (2019-05-02)

Relevant cards

Note: All applicable cards may not be listed below.
SM10_195
SM10_195
SM10_195a
SM10_195a
SM10_219
SM10_219
SM10_57
SM10_57